Labetalol 300 Mg

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Generic name: Labetalol
Marks: Normodyne, Trandate

DRUGS Class and Mechanism: Labetalol is a drug that is used to treat high blood pressure. It is related to carvedilol (Coreg). Nerves that are part of the adrenergic nervous system travel to most arteries where they release an adrenergic chemical norepinephrine. The norepinephrine attaches to receptors on the muscles of the arteries and allows the muscles to contract, narrowing of the arteries and increase blood pressure. Labetalol blocks adrenergic receptors in the nervous system. When labetalol and attaches to block the receptors, the arterial muscles relax, and expand the arteries, causing a drop in blood pressure. The FDA first approved labetalol in 1997.

Generic Available: Yes

PRESCRIPTION: Yes

PREPARATION: Tablets of 100, 200 and 300 mg; Injection: 5 mg / ml

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STORAGE: Tablets should be stored between 2-30 Ā° C (36-86 Ā° F).

Hint: Labetalol is used alone or in combination with other drugs to reduce blood pressure.

Dosage: Labetalol may be given two or three times a day. The initial dose is 100 mg orally twice daily and the dose may be increased by 100 mg twice a day every 2-3 days after the blood pressure response. usual maintenance doses are 200-400 mg twice a day. Patients with severe hypertension may require from 1.2 to 2.4 g per day. Side effects may be less if labetalol is administered in three daily doses rather than two. Stopping or changing the dose of medication should be directed by a doctor because of severe side effects may occur.

The initial dose of intravenous labetalol 20 mg was injected over 2 minutes. additional injections of 40 or 80 mg may be administered every 10 minutes if necessary until a total dose of 300 mg. The maximum effect is usually observed within 5 minutes after intravenous administration. Labetalol may also be administered by intravenous infusion.

INTERACTIONS: Labetalol can mask the symptoms of alert hypoglycemia (low blood sugar), such as tremors and increased heart rate. These symptoms are caused by activation of adrenergic nervous system that blocks labetalol. Therefore, diabetics who take medications that lower blood sugar such as insulin or oral drugs cons diabetes may be necessary to increase the frequency with which they monitor their blood glucose to prevent hypoglycemia.

Labetalol taken with calcium channel blockers such as diltiazem (Cardizem) or verapamil (Calan) may trigger an irregular heartbeat or an increase in blood pressure.

Labetalol taken with tricyclic antidepressants such as amitriptyline (Elavil), imipramine (Tofranil) or nortriptyline (Pamelor) may lead to an increase of the tremor is a side effect of antidepressants.

If taken with adrenergic stimulant used to treat asthma, eg salbutamol (Proventil, Ventolin) or pirbuterol (Maxair), the blocking effects of labetalol may counteract the effects of stimulant drugs and reduce their effectiveness for treating asthma. Over adrenergic drugs may be needed.

Glutethimide (Doriden) may decrease the effectiveness of labetalol by increasing its elimination. When both drugs are used concomitantly, more or less labetalol glutethimide may be necessary. Cimetidine (Tagamet) can increase the effectiveness of labetalol in blocking its disposal and increasing its.